abstract：OBJECTIVE:In Cushing's disease (CD), GH responsiveness to several stimuli, including ghrelin, GHRP-6, and GHRH, is blunted. Recovery of GH secretion after remission of hypercortisolism after transsphenoidal surgery, radiotherapy, or adrenalectomy is controversial. There are no studies evaluating the effect of primary c...

journal_title：European journal of endocrinology

authors： Correa-Silva SR,Nascif SO,Molica P,Sá LB,Vieira JG,Lengyel AM

更新日期：2009-11-01 00:00:00

abstract：:Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question h...

journal_title：European journal of endocrinology

authors： Brabant G,Poll EM,Jönsson P,Polydorou D,Kreitschmann-Andermahr I

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the assoc...

journal_title：European journal of endocrinology

authors： Wehr E,Pilz S,Schweighofer N,Giuliani A,Kopera D,Pieber TR,Obermayer-Pietsch B

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To assess the performance of current clinical recommendations for the evaluation of an adrenal incidentaloma. DESIGN AND METHODS LITERATURE REVIEW: Electronic databases (Pubmed, Ovid and citation searches from key articles) from 1980 to 2008 were searched. Eligible studies were those deemed most applicable to...

journal_title：European journal of endocrinology

authors： Cawood TJ,Hunt PJ,O'Shea D,Cole D,Soule S

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Muscle mass plays an important role in determining cardiovascular and metabolic risks in polycystic ovary syndrome (PCOS). In addition, whether lean mass influences carotid intima-media thickness (IMT) in PCOS has not been assessed. DESIGN:Prospective investigation. METHODS:Ninety-five women with PCOS were ...

journal_title：European journal of endocrinology

authors： Carmina E,Guastella E,Longo RA,Rini GB,Lobo RA

更新日期：2009-10-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：European journal of endocrinology

authors： Funder J,Carey R,Fardella C,Gomez-Sanchez C,Mantero F,Stowasser M,Young W,Montori VM

更新日期：2009-09-30 00:00:00

abstract：OBJECTIVE:Thyroid function parameters have been associated with obesity, but associations with the type of adiposity have not been examined. We used ultrasound (US) to assess regional adiposity and investigated associations of thyroid function with parameters of central obesity. DESIGN:Cross-sectional study. METHODS:...

journal_title：European journal of endocrinology

authors： Alevizaki M,Saltiki K,Voidonikola P,Mantzou E,Papamichael C,Stamatelopoulos K

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To examine the genes for AMP-activated protein kinase (AMPK) subunits alpha2 (PRKAA2) and gamma3 (PRKAG3) as candidates for polycystic ovary syndrome (PCOS) and its component traits. DESIGN AND METHODS:A total of 287 white PCOS women were recruited from the reproductive endocrinology clinic at the University...

journal_title：European journal of endocrinology

authors： Sproul K,Jones MR,Azziz R,Goodarzi MO

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Activating mutations of the vasopressin receptor gene on the X chromosome cause the nephrogenic syndrome of inappropriate antidiuresis (NSIAD). We describe a male child who presented with persistent hyponatraemia and whose mother was also found to be hyponatraemic. She had learnt to avoid excess fluid consum...

journal_title：European journal of endocrinology

authors： Gupta S,Cheetham TD,Lambert HJ,Roberts C,Bourn D,Coulthard MG,Ball SG

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Surgery remains a common form of treatment for sellar and parasellar tumors involving the pituitary gland and adjacent structures. Studies have suggested that pituitary surgery procedures performed at high-volume centers are associated with less adverse outcomes, yet it remains unclear which types of patients...

journal_title：European journal of endocrinology

authors： Mukherjee D,Zaidi HA,Kosztowski T,Chaichana KL,Salvatori R,Chang DC,Quiñones-Hinojosa A

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism (PA) is the most common form of secondary hypertension, while Gitelman's syndrome (GS) is the most common inherited renal tubular disease. However, coexistence of these two diseases has never been previously reported. AIM AND SUBJECTS: The aim of our study was to describe the associatio...

journal_title：European journal of endocrinology

authors： Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

更新日期：2009-08-01 00:00:00

abstract：:The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (PAS type I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III). First clinical manifestation of PAS I usually occurs in childhood, whereas PAS II m...

journal_title：European journal of endocrinology

authors： Kahaly GJ

更新日期：2009-07-01 00:00:00

abstract：DESIGN:In order to characterize whether different degrees of adipose tissue storage may be associated with markers of early atherosclerosis, we evaluated oxidant-antioxidant status and inflammatory markers and determined carotid intima-media thickness (cIMT) in healthy constitutional lean and obese pre-pubertal childre...

journal_title：European journal of endocrinology

authors： Giannini C,de Giorgis T,Scarinci A,Cataldo I,Marcovecchio ML,Chiarelli F,Mohn A

更新日期：2009-07-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Adipokines are involved in the etiopathology of obesity-related disorders. Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationship...

journal_title：European journal of endocrinology

authors： Broch M,Auguet MT,Ramírez R,Olona M,Aguilar C,Megia A,Alcaide MJ,Pastor R,Martínez S,Caubet E,Garcia-España A,Richart C

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Previous evidence has suggested that a low sex hormone-binding globulin (SHBG) concentration is associated with insulin-resistance and a low adiponectin concentration. We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG a...

journal_title：European journal of endocrinology

authors： Bonnet F,Balkau B,Malécot JM,Picard P,Lange C,Fumeron F,Aubert R,Raverot V,Déchaud H,Tichet J,Lecomte P,Pugeat M,DESIR Study Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death. METHOD:Cohort study of 2497 Dutch women. TSH, FT(4), and thyroid peroxidase antibodies concentrations were determined at first booking. Child lo...

journal_title：European journal of endocrinology

authors： Benhadi N,Wiersinga WM,Reitsma JB,Vrijkotte TG,Bonsel GJ

更新日期：2009-06-01 00:00:00

abstract：:Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the ...

journal_title：European journal of endocrinology

authors： Ohlsson C,Vandenput L

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To detect exogenous recombinant human GH (rhGH) abuse in female athletes. DESIGN:GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). METHODS:Cut-off values (mean+2 s.d...

journal_title：European journal of endocrinology

authors： Di Luigi L,Rigamonti AE,Agosti F,Mencarelli M,Sgrò P,Marazzi N,Cella SG,Müller EE,Sartorio A

更新日期：2009-05-01 00:00:00

abstract：:Patients with adrenal insufficiency need lifelong glucocorticoid replacement, but many suffer from poor quality of life, and overall there is increased mortality. Moreover, it appears that use of glucocorticoids at the higher end of the replacement dose range is associated with increased risk for cardiovascular and me...

journal_title：European journal of endocrinology

authors： Debono M,Ross RJ,Newell-Price J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality and morbidity. Little is known about hemostatic features of patients with PHPT. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels...

journal_title：European journal of endocrinology

authors： Erem C,Kocak M,Nuhoglu I,Yilmaz M,Ucuncu O

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:17-Hydroxyprogesterone (17-OHP) screening for classical congenital adrenal hyperplasia (CAH) is part of many newborn screening programs worldwide. Cut-off values are relatively high, and screening sensitivity does not reach 100%. Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to rela...

journal_title：European journal of endocrinology

authors： Schreiner F,Tozakidou M,Maslak R,Holtkamp U,Peter M,Gohlke B,Woelfle J

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Height variability is largely under genetic control, although identifying the genetic variants involved has been until recently challenging. Smallness for gestational age (SGA) is a risk factor for adult short stature. Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs1...

journal_title：European journal of endocrinology

authors： Bouatia-Naji N,Marchand M,Cavalcanti-Proença C,Daghmoun S,Durand E,Tichet J,Marre M,Balkau B,Froguel P,Lévy-Marchal C

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:KLF7 encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified in K...

journal_title：European journal of endocrinology

authors： Zobel DP,Andreasen CH,Burgdorf KS,Andersson EA,Sandbaek A,Lauritzen T,Borch-Johnsen K,Jørgensen T,Maeda S,Nakamura Y,Eiberg H,Pedersen O,Hansen T

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia. DESIGN:Clinical evaluation and genetic analysis of CASR gene. Functional characterization of mutated CASRs. METHODS:Direct sequencing of CASR gene in...

journal_title：European journal of endocrinology

authors： Cetani F,Lemmi M,Cervia D,Borsari S,Cianferotti L,Pardi E,Ambrogini E,Banti C,Brown EM,Bagnoli P,Pinchera A,Marcocci C

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones (TH)s and urinary iodine concentration (UIC) in healthy pr...

journal_title：European journal of endocrinology

authors： Alvarez-Pedrerol M,Guxens M,Mendez M,Canet Y,Martorell R,Espada M,Plana E,Rebagliato M,Sunyer J

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To estimate the incidence of nutritional rickets and the incidence and prevalence of hereditary rickets. DESIGN:Population-based retrospective cohort study based on a review of medical records. METHODS:Patients aged 0-14.9 years referred to or discharged from hospitals in southern Denmark from 1985 to 2005 ...

journal_title：European journal of endocrinology

authors： Beck-Nielsen SS,Brock-Jacobsen B,Gram J,Brixen K,Jensen TK

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

journal_title：European journal of endocrinology

authors： Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...

journal_title：European journal of endocrinology

authors： Vos XG,Smit N,Endert E,Brosschot JF,Tijssen JG,Wiersinga WM

更新日期：2009-02-01 00:00:00

abstract：:The GH/IGF1 axis may play an important role in cognitive function. This theory is supported by the finding that both GH and IGF1 receptors are located in several brain areas such as the hippocampus, a brain area that is known to play an essential role in cognitive processes, especially memory and learning. However, th...

journal_title：European journal of endocrinology

authors： van Nieuwpoort IC,Drent ML

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

journal_title：European journal of endocrinology

authors： Sneve M,Figenschau Y,Jorde R

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:In polycystic ovary syndrome (PCOS), insulin resistance (IR) appears with high prevalence and represents the major cause of cardiometabolic complications. Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. The impact of lipin 1beta expression in visceral and subcutaneous adipose tissue o...

journal_title：European journal of endocrinology

authors： Mlinar B,Pfeifer M,Vrtacnik-Bokal E,Jensterle M,Marc J

更新日期：2008-12-01 00:00:00

abstract：:Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity. In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of...

journal_title：European journal of endocrinology

authors： Delemarre EM,Felius B,Delemarre-van de Waal HA

更新日期：2008-12-01 00:00:00

abstract：:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the pot...

journal_title：European journal of endocrinology

authors： Hew-Butler T,Noakes TD,Soldin SJ,Verbalis JG

更新日期：2008-12-01 00:00:00

abstract：:Descent of the testis from an intra-abdominal site in foetal life to an extracorporeal location after birth is a mandatory developmental process to ensure that the mature testis promotes normal spermatogenesis. The two phases of transabdominal and inguinoscrotal descent occur approximately during the first and last th...

journal_title：European journal of endocrinology

authors： Hughes IA,Acerini CL

更新日期：2008-12-01 00:00:00

abstract：:Osteoporosis is being increasingly recognised in paediatric practice as a consequence of several factors. These include the increasing complexity of chronic conditions and the associated treatments managed by paediatricians. In addition, the improved care provided to children with chronic illness has led to many of th...

journal_title：European journal of endocrinology

authors： Shaw NJ

更新日期：2008-12-01 00:00:00

abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

journal_title：European journal of endocrinology

authors： Gharib H,Papini E,Paschke R

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Recent trials suggest that using ergot-derived dopamine agonists such as cabergoline in the treatment of Parkinson's disease is associated with an increased risk of valvular heart disease. However, the dose of cabergoline used to treat hyperprolactinaemia is considerably less than that used in Parkinson's dis...

journal_title：European journal of endocrinology

authors： Wakil A,Rigby AS,Clark AL,Kallvikbacka-Bennett A,Atkin SL

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Gastric carcinoid tumours type 1 (GCA1) originate from hyperplastic enterochromaffin-like (ECL) cells secondary to hypergastrinaemia. Treatment with somatostatin analogues (SSA) might impede ECL-cell hyperplasia by suppressing gastrin secretion and/or by a direct anti-proliferative effect on ECL cells. We co...

journal_title：European journal of endocrinology

authors： Grozinsky-Glasberg S,Kaltsas G,Gur C,Gal E,Thomas D,Fichman S,Alexandraki K,Barak D,Glaser B,Shimon I,Gross DJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Hypochondroplasia (HCH) is a skeletal dysplasia inherited in an autosomal dominant manner due, in most cases, to mutations in the fibroblast growth factor receptor 3 (FGFR3). Acanthosis nigricans (AN) is a velvety and papillomatous pigmented hyperkeratosis of the skin, which has been recognized in some genet...

journal_title：European journal of endocrinology

authors： Castro-Feijóo L,Loidi L,Vidal A,Parajes S,Rosón E,Alvarez A,Cabanas P,Barreiro J,Alonso A,Domínguez F,Pombo M

更新日期：2008-09-01 00:00:00